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Eva Bentmann
Haass Lab
Adolf-Butenandt-Institute & German Center for Neurodegenerative Diseases (DZNE) Munich, Schillerstraße 44, 80336 Munich
+89 2180 75 474
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Cytoplasmic inclusions of TAR DNA binding protein of 43kDa (TDP-43) and Fused in Sarcoma (FUS) are a hallmark of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Although both proteins are predominately nuclear and involved in various nuclear processes such as transcription, pre-mRNA splicing and mRNA transport, the pathological inclusions are mostly observed in the cytoplasm. Interestingly, familial ALS associated FUS-mutations impair the nuclear import of FUS. Upon cellular stress, cytoplasmically mislocalized FUS-mutants are sequestered into stress granules, reversible cytosolic structures which store mRNA during environmental stress conditions. Additionally, FUS- and TDP-43- positive inclusions are frequently labeled with stress granule marker proteins, suggesting that stress granules might be the precursors of the pathological inclusions. To gain insights in the mechanisms leading to pathological FUS and TDP-43 inclusions I study the recruitment of FUS and TDP-43 into stress granules and aim to understand how reversible stress granules can be converted into irreversible pathological inclusions.

since 04/2012: Graduate program „Protein Dynamics in Heath and Disease“, Elite Network of Bavaria


since 01/2010: PhD thesis in the lab of Prof. Dr. Dr. h.c. Christian Haass (under the direction of Dr. Dorothee Dormann)


07/2009 -12/2009: Graduate research assistant, Prof. Dr Sendtner, Institute for Clinical Neurobiology, Clinical University of Wuerzburg


07/2008 – 06/2009: Diploma thesis, “Knockdown of Vps54 by shRNA in primary motoneurons and investigation of sALS-specific SNPs in the Vps54 gene”


07/2007- 10/2007: internship at MACSmolecular R & D, Miltenyi Biotec, Cologne


10/2003 – 06/2009: Studies of Biology at the University of Wuerzburg

Dormann D, Madl T, Tahirovic S, Bentmann E, Abou-Ajram C, Haass C. Arginine Methylation next to the PY-NLS modulates Transportin Binding and Nuclear Import of Fused in Sarcoma Under revision


Bentmann E, Neumann M, Tahirovic S, Rodde R, Dormann D*, Haass C*. Requirement for Stress Granule Recruitment of FUS and TDP-43. J Biol Chem Epub 2012 May 4


Neumann M, Bentmann E, Dormann D, Jawaid A, Dejesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, Mackenzie IR. FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain. 2011 Sep;134(Pt 9):2595-609. Epub 2011 Aug 19.


Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C. ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. EMBO J. 2010 Aug 18;29(16):2841-57. Epub 2010 Jul 6.


Posters:

Bentmann E, Neumann M, Tahirovic S, Rodde R, Dormann D*, Haass C*. Requirement for Stress Granule Recruitment of FUS and TDP-43. 32nd Blankenese Conference, Neurodegeneration: From MS to AD, Hamburg-Blankenese, Germany, 19-23 Mai 2012


Bentmann E*, Dormann D*, Rodde R, Neumann M, Haass C. Differential Requirement for Stress Granule Recruitment of FUS and TDP-43. 6th Brain Res Conference: RNA Binding Proteins in Neurological Disease, Washington, USA, 10-11 November 2011


Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C. ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. Eibsee Meeting 2010, Grainau, Germany, October 27-30, 2010

*equal contribution








Poster Award sponsored by FEBS J at the 32nd Blankenese Conference, Neurodegeneration: From MS to AD (05/2012)


Travel grant, Blankenese Conference (05/2012)


Travel grant, CIPSM Frauenförderung (11/2011)




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Eva Bentmann
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