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Amelie Ebke
Haass Lab
Schillerstr. 44
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  • Protein biochemistry of intramembrane proteases
  • Mechanisms of neurodegeneration
  • Since 06/2013: Research associate at the Fraunhofer Institute for Systems and Innovation Research, Karlsruhe
  • 02/2013 - 05/2013: Postdoctoral fellow, γ-secretase group, Prof. Steiner & Prof. Haass, Adolf-Butenandt-Institute, LMU Munich & German Center for Neurodegenerative Diseases (DZNE)
  • 01/2009 - 09/2012: PhD thesis summa cum laude, γ-secretase group, Prof. Steiner & Prof. Haass, Adolf-Butenandt-Institute, LMU Munich & German Center for Neurodegenerative Diseases (DZNE); title: "γ-Secretase modulators as potential therapeutics for Alzheimer's disease: Mechanism of action and molecular targets"
  • 07 - 12/2008: Internship at the editorial office of Elsevier Urban & Fischer Verlag GmbH, Munich
  • 09/2007 - 05/2008: Diploma thesis at the MPI for Biochemistry, chromosome segregation group, Prof. Jentsch & PD Dr. Stemmann, Department of Molecular Cell Biology; title: "Repeated use of site-specific recombination to rapidly generate stable cell lines expressing multiple (inducible) transgenes"
  • 2003 - 2008: Studies of Biology, LMU Munich
  • 2006 - 2007: Student assistant at the MPI for Biochemistry, chromosome segregation group, Prof. Jentsch & PD Dr. Stemmann, Department of Molecular Cell Biology
  • 2002 - 2003: Cultural and business studies, University of Passau
  • 2002: Abitur (German advanced school leaving exam) at the Werner-Heisenberg-Gymnasium, Garching

Papers:

  • Page RM, Gutsmiedl A, Fukumori A, Winkler E, Haass C and Steiner H. β-Amyloid precursor protein mutants respond to γ-secretase modulators. J Biol Chem 2010, 285(23): 17798-810.
  • Kretner B, Fukumori A, Gutsmiedl A, Page RM, Luebbers T, Galley G, Baumann K, Haass C and Steiner H. Attenuated Aβ42 responses to low potency γ-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds. J Biol Chem 2011, 286(17): 15240-51.
  • Ebke A, Luebbers T, Fukumori A, Shirotani K, Baumann K, Haass C and Steiner H. Novel γ-secretase enzyme modulators directly target presenilin protein. J Biol Chem 2011, 286(43): 37181-6.
  • Winkler E, Kamp F, Scheuring J, Ebke A, Fukumori A and Steiner H. Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness. J Biol Chem 2012, 287(25): 21326-34.

Talk:

  • 7th Fabisch Symposium for Cancer Research and Molecular Cell Biology - Regulated Intramembrane Proteolysis in Cancer Development and Neurodegenerative Diseases, Potsdam, October 5-7, 2011: Novel γ-secretase modulators directly target presenilin. Ebke A et al.

Posters:

  • 9th Eibsee Meeting „Cellular Mechanisms of Alzheimer's Disease“, Grainau, November 11-14, 2009: Modulation of Aβ generation is effective for FAD-associated and artificial mutations of APP. Page RM, Gutsmiedl A, Fukumori A, Winkler E, Haass C and Steiner H.
  • PhD symposium „interact“, Munich, March 23, 2010: Characterization of novel γ-secretase modulators in vitro. Gutsmiedl A, Baumann K, Winkler E, Haass C, Steiner H.
  • 10th International Conference on Alzheimer's & Parkinson's Disease, Barcelona, March 9-13, 2011: In vitro characterization of novel Aβ42-lowering γ-secretase modulators. Gutsmiedl A, Fukumori A, Luebbers T, Winkler E, Haass C, Baumann K and Steiner H.
  • 11th Eibsee Meeting „Cellular Mechanisms of Neurodegeneration“, Grainau, October 12-15, 2011: Novel γ-secretase modulators directly target presenilin. Ebke A, Luebbers T, Fukumori A, Shirotani K, Baumann K, Haass C and Steiner H.
  • Empiris Award for Research in Brain Diseases 2012, presented by the Empiris Foundation, endowed with CHF 10.000
  • Award for the best short talk at the 7th Fabisch Symposium for Cancer Research and Molecular Cell Biology, October 5-7, 2011.
  • 2002 - 2007: Scholarship after the "Bayerisches Begabtenförderungsgesetz" (BayBFG)
  • 07/2011: Organization of the 'Advanced Scientific Writing' Workshop by Ruth Wilmott
  • 05/2012: Organization of the 'Career Mentoring and Management' Workshop by Ruth Wilmott
  • Graduate program "Neurodegenerative Disease Research", SFB 596, LMU Munich
  • VBIO - Verband für Biologie, Biowissenschaften & Biomedizin in Deutschland e.V.
  • GBM - Gesellschaft für Biochemie und Molekularbiologie e.V.
  • Abaco Orchester e.V.
Research Associate at the Fraunhofer Institute for Systems and Innovation Research, Karlsruhe
edoc.ub.uni-muenchen.de/15573/

Contact Info

Amelie Ebke
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Alumni
Biochemistry